MELiSSA Patents

EMEY J., LASSEUR Ch. "Cholestrol-lowering preparation food supplement, and foodstuff, and methods for preparing same" Intenational Publication Number: WO 2004/052380 A1

LASSEUR Ch., VERSTRAETE W., RICHALET J. "Process and equipment for organic waste treatment and applications of the process" French patent 9602131, ESA, 21/2/96.

Phase 1

MERGEAY M., VERSTRAETE W., DUBERTRET G., LEFORT-TRAN M., CHIPAUX C. BINOT R. "MELISSA - a microorganisms based model for CELSS development" Proceedings of the 3rd symposium on space thermal control & life support system, Noordwijk, The Netherlands, October 3-6, 1988

BINOT R., MERGEAY M. "Melissa: a model of a closed microbial ecosystem for spatial purposes and a potential tool in exobiology" 28th COSPAR, The Hague, The Netherlands, June 25- July 6, 1990

CHRISTIAENS H., VERSTRAETE W. "Anaerobic elements recycling for artificial closed ecosystems" Workshop on artificial ecological systems, DARA-CNES, Marseille, France, October 24-26, 1990

CORNET J.F., DUBERTRET G. "The cyanobacterium Spirulina in the photosynthetic compartment of the MELISSA artificial ecosystem" Workshop on artificial ecological systems, DARA-CNES, Marseille, France, October 24-26, 1990

CORNET J.F., DUSSAP C.G., DUBERTRET G., GROS J.B. "Modelling light transfer inside photobiofermentors. Applications to the photosynthetic compartment of C.E.L.S.S." Proceedings of the 4th European Symposium on Space Environmental and Control Systems, Florence, Italy, October 21-24, 1991

BINOT R.A., GALLART F., SAVAGE C.J. "European closed ecological systems: its history and future" ESA internal document (1991)

BINOT R.A., TAMPONNET C., LASSEUR C. "Biological life support for manned missions by ESA" Adv. Space. Res.(1994), 14(11): 71-74

JANSEN P., MERGEAY M. "Thiocapsa Roseopersicina, a bacterium for sulfur recycling in microbial ecosystems designed for CELSS and space purposes" 4th European symposium on space environmental and control systems (ESA.SP 324), Florence, Italy, October 21-24, 1991

LASSEUR C., BINOT R.A "Control system for artificial ecosystems. Application to MELISSA" 21st International Conference on Environmental Systems, San Francisco, USA, July 15-18, 1991

LASSEUR C., BINOT R.A., TAMPONNET C., CORNET J.F. "MELISSA: Physical link of compartments Nitrobacter / Spirulina" 4th European symposium on space environmental and control systems (ESA.SP 324), Florence, Italy, October 21-24, 1991

DUSSAP C.G., CORNET J.F., GROS J.B. "Simulation of mass fluxes in the MELISSA microorganism based ecosystem" Proceedings of the 23rd International Conference on Environmental Systems, Colorado springs, USA, July 12-15, 1993

COGNE G., LEHMANN B., DUSSAP CG., GROS JB. "Uptake of macrominerals and trace elements by the cyanobacterium Spirulina platensis (Arthrospira platensis PCC8005) under photoautotrophic conditions: Culture medium optimisation" Biothechnol. Bioeng.(2003), 81(5): 588-93

CORNET J.F., ALBIOL J. "Modelling photoheterotrophic growth kinetics of Rhodospirillum rubrum in rectangular photo bioreactors" Biotechnol. Prog.(2000), 16: 199-207

LASSEUR C., TAMPONNET C. "MELISSA: current status and future development program" Proceedings of the 23rd International Conference on Environmental Systems, Colorado springs, USA, July 12-15, 1993

CORNET J.F., DUSSAP C.G., CLUZEL P., DUBERTRET G. "A structured model simulation of cultures of the cyanobacterium: II Identification of kinetic parameter under light and mineral limitations" Biotechnol. & Bioeng.(1992), 40: 826-834

CORNET J.F., DUSSAP C.G., DUBERTRET G "A structured model for simulation of cultures of the cyanobacterium: I coupling between light transfer and growth kinetics" Biotechnol. & Bioeng.(1992), 40: 817-825

ALBIOL J., GICQUEAU B., LASSEUR C. "Preliminary studies on the performance and behaviour of the MELISSA photoheterotrophic compartment" 24th International Congress on Environmental Control Systems, Friedrichshafen, Germany, June 20-23, 1994

CORNET J.F., DUSSAP C.G., GROS J.B. "Conversion of radiant light energy in photobioreactors" A.I.Ch.E Journal(1994), 40(6): 1055-1066

CORNET J.F., DUSSAP C.G., GROS J.B. "Kinetics and energetics of photosynthetic micro-organisms in photobioreactors- Application to Spirulina growth" Advances in Biochemical Engineering/Biotechnology(1998), 59: 153-224

CORNET J.F., DUSSAP C.G., GROS J.B., BINOIS C., LASSEUR C. "A simplified monodimmensionnal approach for modeling coupling between radiant light transfer and growth kinetics in photobioreactors" Chemical Engineering Science(1995), 50(9): 1489-1500

CORNET J.F., DUSSAP C.G., LECLERCQ J.J. "Simulation, Design and Model based Predictive Control of Photobioreactors" In:Focus on Biotechnology, vol. 4: Engineering and Manufacturing for Biotechnology Ed. Kluwer Academic Publishers, Dordrecht, 2001, 227-238

CORNET J.F., MARTY A., GROS J.B. "Revised technique for the determination of mean incident light fluxes on photobioreactors" Biotechnol. Progress(1997), 13: 408-415

BINOIS C., LASSEUR C., CORNET J.F., DOYLE D. "Model based predictive of MELISSA photobioreactors. Steady state determination" 24th International Congress on Environmental Control Systems, Friedrichshafen, Germany, June 20-23, 1994

MEHEUS L., KERSTERS I. "The liquefying compartment in the MELISSA cycle: evaluation of three thermophilic strains" 24th International Conference on Environmental Systems (SAE 941346) and 5th European Symposium on space Environmental Control System, Friedrichshafen, Germany, June 20-23, 1994

POUGHON L., DUSSAP C.G., CORNET J.F., GROS J.B "MELISSA: behaviour of the ecosystem under different light radiant energy inputs" 24th International Congress on Environmental Control Systems, Friedrichshafen, Germany, June, 1994

ZEGHAL S., BEN YAHIA L., LASSEUR C., ROGALLA F. "Study of the nitrifying compartment in MELISSA" 24th International Congress on Environmental Control Systems, Friedrichshafen, Germany, June, 1994

ALBIOL J., GODIA F. CORNET J.F., GROS J.B. "Model validation for growth kinetics of R.rubrum under light limitation" 6th European Symposium on Space Environmental Control Systems (ESA SP-400, Aug. 1997), Noordwijk, The Netherlands, May 20-22, 1997

FAVIER-TEODORESCU L., CORNET J.F., DUSSAP C.G. "Modelling Continuous Culture of Rhodospirillum rubrum in Photobioreactor under light limited Conditions" Biotechnology Letters(2003), 25: 359-364

FILALI-MOUHIM R., CORNET J.F., FONTAINE T., FOURNET B., DUBERTRET G. "Production isolation and preliminary characterisation of the exopolysaccharide of the cyanobacterium Spirulina platensis" Biotechnology Letters(1993), 15(6): 567-572

ALBIOL J., GODIA F., VERNEREY A. "Effects of light intensity and nitrate limitation on biomass composition of Spirulina platensis" 6th European Symposium on Space Environmental Control Systems (ESA SP-400, Aug. 1997), Noordwijk, The Netherlands, May 20-22, 1997

FULGET N., POUGHON L., RICHALET J., LASSEUR C. "MELISSA, global control strategy of the artificial ecosystem by using first principles models of the compartments" Adv. Space Res.(1999), 24(3): 397-405

DEMEY D., VAN MEENEN P. "Anaerobic thermophilic biodegradation of faecal material" Proceedings of the 6th European Symposium on Space Environmental Control Systems, Noordwijk, The Netherlands, May 20-22, 1997

GROS J.B., CORNET J.F., DUSSAP C.G., LASSEUR C. "Melissa: un modele d'ecosysteme artificiel pour des missions spatiales de longue duree" Les environnements artificiels, Dossier de la revue de geographie alpine(1997), 19: 93-98

GROS J.B., DUSSAP C.G., POUGHON L, LASSEUR C. "Un exemple d'ecosysteme artificiel : MELISSA, Simulation du comportement de la boucle" Recents progres en genie des procedes (1995), 9 (42): 261-266

GROS J.B., LASSEUR C., VERSTRAETE W. "MELISSA : ecosysteme ou unite de retraitement des dechets" Biofutur, Le technoscope(1994), : 35-37

GROS J.B., POUGHON L., LASSEUR C., LECLERCQ J.J. "Recycling efficiencies of CHONSP elements in a Biological Life Support System based on microorganisms and higher plants" Adv. Space Res.(2003), 31(1): 195-199

FILALI-MOUHIM R., LASSEUR C., DUBERTRET G "MELISSA: nitrogen sources for growth of the cyanobacterium Spirulina" Proceedings of the 6th European Symposium on Space Environmental Control Systems, Noordwijk, The Netherlands, May 20-22, 1997

POUGHON L., DUSSAP C.G., GROS J.B. "Preliminary study and simulation of the MELISSA loop including a higher plant compartment" Proceedings of the 6th European Symposium on Space Environmental Control Systems (ESA SP-400) , Noordwijk, The Netherlands, May 20-22, 1997

KERSTERS I., HOUWEN F., VERSTRAETE W. "Thermophilic anaerobic degradation of gelatine by thermobacteroides proteolyticus" Biotechnology letters (1993), 15(9): 931-936

KERSTERS I., MAESTROJUAN GM., TORCK, U., VANCANNEYT M., KERSTERS K, VERSTRAETE W "Isolation of Coprothermobacter proteolyticus from an anaerobic digest and further characterisation of the species" System. Appl. Microbiol.(1994), 17: 289-295

LASSEUR C. "MELISSA: A model of an artificial ecosystem" Preparing For the Future ESA's Technology program(1994), 4(1): 12-13

VAN ROY S., MERGEAY M., DIELS L. "Combination of the anaerobic liquefying and the phototrophic compartments of MELISSA in a membrane bioreactor" Proceedings of the 6th European Symposium on Space Environmental Control Systems, Noordwijk, The Netherlands, May 20-22, 1997

CLOUTIER G.R., COTE R., STASIAK M.A., DIXON M.A., ARNOLD K.E. "Physiological Aspects of Integrated Crop Production in Advanced Life Support Systems" 28th International Conference on Environmental Systems (SAE 981561), Danvers, USA, July 13-16, 1998

RICHALET J., FULGET N., LECLERCQ J.J. "The control system of the MELISSA ecosystem" ISEM, Baltimore, USA, August 2-6, 1998

POUGHON L., GROS J.B., DUSSAP C.G. "Mass balance and stoechiometry in modelling artificial ecosystems" Workshop on advanced life Support, Noordwijk, The Netherlands, April 13-14, 1999

WICHERS H.J, ECKHARD F., LASSEUR C. "FOOD: fungus on orbit demonstration" 50th IAF, , The Netherlands, October 4-8, 1999

LASSEUR C., VERSTRAETE W., GROS J.B., DUBERTRET G., ROGALLA F. "MELISSA: a potential experiment for a precursor mission to the Moon" Adv. Space Res.(1996), 18(11): 111-117

LISSENS G., VERSTRAETE W., ALBRECHT T., BRUNNER G., CREULY C., DUSSAP G. "Advanced hydrolysis and methanogenesis for the complete and biosafe conversion of organic waste in a life support system" Med. Fac. Landboouww. Univ. Gent(2002), 67(4): 179-182

CLOUTIER G., DIXON M "Modeling plant canopy photosynthetic capacity a comparison of non-linera, parametric and non-parametric approaches" 30th International Conference on Environmental Systems (SAE paper 2293), Toulouse, France, July 10-13, 2000

MARTY A., CORNET J.F., DJELVEH G., LARROCHE C., GROS J.B. "A gas phase chromatography method for determination of low dissolved CO2 concentration and/or CO2 solubility in microbial culture media" Biotechnology Techniques(1995), : 787-792

HERMANS V., DEMEY D. "Anaerobic thermophilic biodegradation: pre-treatment of faecal material" 30th International Conference on Environmental Systems (SAE paper 2283), Toulouse, France, July 10-13, 2000

MORIST A., MONTESINOS J.L., CUSIDO J.A., GODIA F. "Recovery and treatment of Spirulina platensis cells cultured in a continuous photobioreactor to be used as food" Process Biochemistry(2001), 37: 535-547

LASSEUR C., DIXON M., DUBERTRET G., DUSSAP C.G. GODIA F., GROS J.B., MERGEAY M., RICHALET J., VERSTRAETE W. "MELISSA: 10 years of research, results status and perspectives" 30th International Conference on Environmental Systems (SAE 2378), Toulouse, France, July 10-13, 2000

LASSEUR C., SCHMITT D "Biological Life Support within ESA, Past and future developments" 30th International Conference on Environmental Systems (SAE paper 2338), Toulouse, France, July 10-13, 2000

POUGHON L., DUCHEZ D., CORNET J.F., DUSSAP C.G. "KLa determination: comparative study for a gas mass balance method" Bioprocess Biosyst. Eng. (2003), 25: 341-348

MARIN-VINADER L., ECKHARD F., LASSEUR C., WICHERS, H.J., SOLER RIVAS C. "Potential role of fungi for long term manned space missions" Proceedings of the 15th International Congress on the Science and Cultivation of Edible Fungi, Maastricht, The Netherlands, May 15-19, 2000

POUGHON L., DUSSAP C.G., GROS J.B "Dynamic model of a nitrifying fixed bed column: simulation of the biomass distribution of Nitrosomonas and Nitrobacter and of transient behaviour of the column" Bioprocess Engineering (1999), 20(3): 209-221

POUGHON L., DUSSAP C.G., GROS J.B. "Energy model and metabolic flux analysis for autotrophic nitrifiers" Biotechnology and Bioengineering(2001), 72(4): 416-433

POUGHON L., GROS J.B., DUSSAP C.G. "MELISSA loop first estimates of flow rates and concentration through the loops" 30th International Conference on Environmental Systems (SAE paper 2380), Toulouse, France, July 10-13, 2000

SOLER-RIVAS C., WICHERS H., ECKHARD F., LASSEUR C. "FOOD: fungus on orbit demonstration" 30th International Conference on Environmental Systems (SAE paper 2382), Toulouse, France, July 10-13, 2000

TIKHOMIROV A.A., LISOVSKY G.M., GITELSON JI. "Closed life support systems as an impetus to advanced technology development" Proceedings of the International Symposium on Impact of Space Technology Innovation on Economic Development, Shangai, China, April 17-20, 2001

TIKHOMIROV A.A., USHAKOVA S.A., GRIBOVSKAYA I.A., TIRRANENL.S., MANUKOVSKY N.S., ZOLOTUKHIN I.G., KARNACHUK R.A., GROS J.B., LASSEUR C. "Light intensity and production parameters of phytocenoses cultivated on soil-like substrate under controlled environment conditions" 53rd International Astronautical Congress. The World Space Congress-2002, Houston, Texas, USA, October 10-19, 2002

SAVAGE C.J., TAN G.B.T., LASSEUR C. "ESA developments in life support technology: achievements and future priorities" Acta Astronautica (2001), 49(3): 331-344

SEON J., CREULY D., DUCHEZ D., PONS A., DUSSAP C.G. "Degradation of plant wastes by anaerobic process using rumen bacteria" Water Science And Technology(2003), 4(48): 213-216

TIKHOMIROV A.A., USHAKOVA S.A., MANUKOVSKY N.S., LISOVSKY G.M., KUDENKO Y.A., KOVALEV V.S., GRIBOVSKAYA I.V., TIRRANEN L.S., ZOLOTUKHIN I.G., GROS J.B., LASSEUR C. "Synthesis of biomass and utilisation of plants wastes in a physical model of biological life-support system" 53rd International Astronautical Congress. The World Space Congress-2002, Houston, Texas, USA, October 10-19, 2002

TAMPONNET C., BINOT R., LASSEUR C., SAVAGE C "Man in space - A European challenge in biological life support" ESA bulletin(1991), 67: 39-49

TIKHOMIROV A.A., USHAKOVA S.A., MANUKOVSKY N.S., LISOVSKY G.M., KUDENKO Y.A., KOVALEV V.S., GUBANOV V.G., BARKHATOV Y.V., GRIBOVSKAYA I.V., ZOLOTUKHIN I.G., GROS J.B., LASSEUR C. "Mass exchange in an experimental new-generation LSS model based on a biological regeneration of environment" 53rd International Astronautical Congress. The World Space Congress-2002, Houston, Texas, USA, October 10-19, 2002

HENDRICKX L, JANSSEN P, BAATOUT S, MARTY F, MERGEAY M, WATTIEZ R, WILMOTTE A, PAILLE C "Stability and Axenicity in the MELiSSA loop" International Conference on Environmental Systems (SAE 2003-01-2418), Vancouver, Canada, July, 2003

ORDONEZ L., RODRIGUEZ A. "Static and dynamic analysis of the MELISSA loop using EcosimPro" Second EcosimPro Users Meeting, Madrid, Spain, February 24-25, 2003

TRANQUILLE N., EMEIS J.J., DE CHAMBURE D., BINOT R.A., TAMPONNET C. "Spirulina acceptability trials in rats. A study for the MELISSA life support system" Adv. Space Res.(1994), 14(11): 167-170

ROSSI N., JAOUEN P,LEGENTILHOMME P, PETIT I "Harvesting of cyanobacterium Arthrospira platensis using organic filtration" SFGP, Saint-Nazaire, France, September 9-11, 2003

VERSTRAETE W., GROS J.B., DIELS L’, DUBERTRET G., GODIA F., RICHALET J., DEMEYS D., LASSEUR C. "MELISSA, a simplified ecosystem for long term manned space missions" Internal communication

WATERS GCR, GIDZINSKI D, ZHENG Y, STASIAK M, DIXON MA "Modelling and trade studies of staged production scenarios in bioregenerative life support systems" ICES (03ICES-160), Vancouver, Canada, July 7-10, 2003

WATERS GCR, OLABI A, HUNTER JB, DIXON MA, LASSEUR C. "Bioregenerative food system cost based on optimized menus for advanced life support " Life Support & Biosphere Science (2002), 8: 199-210

DE WEEVER H., BORREMANS B, DIELS L., DEMEY D., LASSEUR C. "Bioregenerative life support in space missions: degradation efficiency and microbial community stability in an anaerobic liquefying compartment" ESEB, Oostende, Belgium, April 25-28, 2004

ORDONEZ L., POUGHON L., WATERS G., LASSEUR C. "MELiSSA Higher Plants Compartment modelling using Ecosim Pro" ICES, Colorado springs, USA, July 19-22, 2004

DE WEEVER H., BORREMANS B, DIELS L., DEMEY D., LASSEUR C. "Bioregenerative life support in space missions: degradation efficiency and microbial community stability in an anaerobic liquefying compartment" ESEB, , Belgium, April, 2004

Phase 2

DUBERTRET G., LEFORT-TRAN M., CHIPAUX C. "Ecological algal system in microgravity conditions – Preliminary results" 3rd European Symposium on Life Sciences Research in Space (ESA SP271), Graz, Austria, September 14-18, 1987

DUSSAP C.G., VERSTRAETE W., GODIA V., RICHALET J., GROS J.B. "Potential interest for the study of bioprocesses in micro gravity" 1st Symposium on the utilisation of the International Space Station, Florence, 1996

DEMEY D., HERMANS V., CORNET JF., LECLERCQ JJ., LASSEUR C., DELAHAYE A. "BIORAT : preliminary evaluation of biological life support in space environment developments" 30th International Conference on Environmental Systems (SAE paper 2384), Toulouse, France, July 10-13, 2000

PAILLE C., ALBIOL J., CURWY R., LASSEUR C., GODIA F "FEMME, a precursor experiment for the evaluation of bioregenerative Life support systems" Planetary and space sciences (2000), 48: 515-521

PAILLE C., CURWY R., LEHMAN B., DUBERTRET G., FOING B., LASSEUR Ch "FEMME A Precursor ecosystem on the Moon" Adv. Space Res.(1999), 23(11): 1857-1860

PAILLE C., GODIA F., ABIOL J., LASSEUR C. "A preparation for bioregenerative life support systems: the FEMME experiment" ICES (2000-01-2381)(2000)

COGNE G., GROS JB., DUSSAP CG "A simple reliable bioreactor for studying the growth and metabolism of photosynthetic micro-organisms in space" ICES (03ICES-244), Vancouver, Canada, July, 2003

DE WEVER H., VAN HOOF V., DOTREMONT C., DIELS L., DOULAMI F., DEMEY D., JAOUEN P., LASSEUR C. "Harvesting technologies for Arthrospira Platensis in ALSS" International Congress on Bioprocesses in Food Industires, 38154, 2004

Phase 3

GODIA F., ALBIOL J., MONTESINOS J.L., PEREZ J., CREUS N., CABELLO F., MENGUAL X. MONTRAS A., LASSEUR C. "MELISSA a loop of interconnected bioreactors to develop life support in space" Journal of Biotechnology(2002), 99(3): 319-330

GODIA F., ALBIOL J., PEREZ J., CREUS N., CABELLO F., MONTRAS A., MASOT A., LASSEUR C. "MELISSA pilot plant facility as an integration test-bed for advanced life support system" Adv. Space Res.(2004)

GODIA F., ALBIOL J., MONTESINOS J.L., PEREZ J., VERNEREY A., PONS P., LASSEUR C. "MELISSA pilot plant : a facility for the demonstration of a biological concept of a life support system" Proceedings of the 6th European Symposium on Space Environmental Control Systems, Noordwijk, The Netherlands, May 20-22, 1997

ALBIOL J., GODIA F., MONTESINOS J.L., PEREZ J., VERNEREY A., CABELLO A., CREUS N., MORIST A., MENGUAL X., LASSEUR C. "Biological Life support system demonstration facility: the MELISSA pilot plant" 30th International Conference on Enviromental Systems (SAE paper 2379), Toulouse, France, July 10-13, 2000

CREUS N., CABELLO F., PEREZ J., ALBIOL J., GODIA F., LASSEUR C. "Connection between different compartments of the MELISSA biological life support system" 31st International Conference on Environmental Systems, Orlando, USA, , 2001

VERNEREY A., ALBIOL J., LASSEUR C. "Scale-up and design of a pilot plant photobioreactor for the continuous culture of Spirulina platensis" Biotech Progress(2001), 17(3): 431-438

PEREZ J., POUGHON L., DUSSAP G., MOTESINOS JL., GODIA F. "Dynamics and stready state operation of a nitrifying fixed bed biofilm reactor: mathematical model based description" Process Biochemistry (2005), 40: 2359-2369

Phase 4

LASSEUR C., ZEGHAL S., GROS J.B, VERSTRAETE W., RICHALET J "MELISSA: Potential industrial return from the MELISSA project for the terrestrial industry" XI the IAA Man in Space, Toulouse, France, March 27-31, 1995

LASSEUR C., GROS J.B, VERSTRAETE W., RICHALET J, GODIA F. "MELISSA yields potential industrial benefits on Earth" Preparing For the Future(1997), 7(3): 20-21

Associated Projects

MELiSSA Annual reports